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These are the Fugates, also known as The Blue People of Kentucky, they are carriers of a rare genetic trait that causes the disease methemoglobinemia, which causes bluing of the skin :
Methemoglobinemia (Congenital Methemoglobinemia)
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Finding The Famous Painting of the Blue People of Kentucky - DNA Science
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The Fugate Family of Kentucky Had Blue Skin For Generations
Finding The Famous Painting of the Blue People of Kentucky - DNA Science
TIL The Fugates, a family that lived in the hills of Kentucky, commonly known as the "Blue Fugates" or the Blue People of Kentucky, are notable for having been carriers of a
57 Blue Fugates of Kentucky ideas in 2022 | kentucky, blue, appalachian people